Monotherapy Vs Polytherapy In Epilepsy

Monotherapy Vs Polytherapy In Epilepsy. Monotherapy has been promoted as the ideal in epilepsy treatment because of reduced side effects absence of drug interactions better compliance lower cost and in many cases improved seizure control compared to polytherapy The question of monotherapy vs polytherapy has assumed increasing importance with the availability of multiple new antiepileptic drugs (AEDs).

Univariate analysis showed that patients treated with polytherapy had an older onset age (median = 160 vs 130 years mean = 215 vs 170 years p = 0041) and a longer duration of epilepsy before treatment (median = 240 vs 80 months mean = 512 vs 260 months p = 0035) compared to those treated with monotherapy.

Monotherapy or polytherapy for epilepsy?

PDF filetoxicity between monotherapy and polytherapy Key Words Epilepsy—Polytherapy—Trial—Drug load—Neurotoxicity Monotherapy has been the gold standard of epilepsy treatment for the last 20 years This was brought about by a series of open trials by Reynolds and Shorvon (1–3) in which they showed that epilepsy patients could be effec.

Monotherapy versus Polytherapy in Epileptic Adolescents

PDF fileoptimize polytherapy drug choices in the treatment of patients with epilepsy II Key Definitions and Concepts Monotherapy Use of a single drug at a time to treat a disease symptom or condition Polytherapy Use of more than one drug or therapy at a time to treat a disease symptom or condition.

Comparison of LongTerm Outcomes of Monotherapy and

For the past 30 years a dogma of epilepsy treatment has been to start with monotherapy 1 This still makes sense for several reasons cost lower risk of side effects better compliance and avoidance of pharmacokinetic (PK) and pharmacodynamic (PD) drug interactions 2 Furthermore data from many studies indicate that initial monotherapy produces.